Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin.
Identifieur interne : 000408 ( Main/Exploration ); précédent : 000407; suivant : 000409Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin.
Auteurs : Zhen He [États-Unis, République populaire de Chine] ; Raad Z. Gharaibeh [États-Unis] ; Rachel C. Newsome [États-Unis] ; Jllian L. Pope [États-Unis] ; Michael W. Dougherty [États-Unis] ; Sarah Tomkovich [États-Unis] ; Benoit Pons [France] ; Gladys Mirey [France] ; Julien Vignard [France] ; David R. Hendrixson [États-Unis] ; Christian Jobin [États-Unis]Source :
- Gut [ 1468-3288 ] ; 2019.
Descripteurs français
- KwdFr :
- ADN tumoral (analyse), ARN tumoral (analyse), Altération de l'ADN (MeSH), Animaux (MeSH), Campylobacter jejuni (génétique), Campylobacter jejuni (isolement et purification), Campylobacter jejuni (pathogénicité), Carcinogenèse (MeSH), Expression des gènes (MeSH), Fèces (microbiologie), Humains (MeSH), Microbiome gastro-intestinal (MeSH), Sirolimus (pharmacologie), Souris (MeSH), Toxines bactériennes (toxicité), Transcriptome (MeSH), Tumeurs colorectales (génétique), Tumeurs colorectales (microbiologie).
- MESH :
- analyse : ADN tumoral, ARN tumoral.
- génétique : Campylobacter jejuni, Tumeurs colorectales.
- isolement et purification : Campylobacter jejuni.
- microbiologie : Fèces, Tumeurs colorectales.
- pathogénicité : Campylobacter jejuni.
- pharmacologie : Sirolimus.
- toxicité : Toxines bactériennes.
- Altération de l'ADN, Animaux, Carcinogenèse, Expression des gènes, Humains, Microbiome gastro-intestinal, Souris, Transcriptome.
English descriptors
- KwdEn :
- Animals (MeSH), Bacterial Toxins (toxicity), Campylobacter jejuni (genetics), Campylobacter jejuni (isolation & purification), Campylobacter jejuni (pathogenicity), Carcinogenesis (MeSH), Colorectal Neoplasms (genetics), Colorectal Neoplasms (microbiology), DNA Damage (MeSH), DNA, Neoplasm (analysis), Feces (microbiology), Gastrointestinal Microbiome (MeSH), Gene Expression (MeSH), Humans (MeSH), Mice (MeSH), RNA, Neoplasm (analysis), Sirolimus (pharmacology), Transcriptome (MeSH).
- MESH :
- chemical , analysis : DNA, Neoplasm, RNA, Neoplasm.
- chemical , pharmacology : Sirolimus.
- chemical , toxicity : Bacterial Toxins.
- genetics : Campylobacter jejuni, Colorectal Neoplasms.
- isolation & purification : Campylobacter jejuni.
- microbiology : Colorectal Neoplasms, Feces.
- pathogenicity : Campylobacter jejuni.
- Animals, Carcinogenesis, DNA Damage, Gastrointestinal Microbiome, Gene Expression, Humans, Mice, Transcriptome.
Abstract
OBJECTIVE
DESIGN
Germ-free (GF)
RESULTS
GF
CONCLUSION
Human clinical isolate
DOI: 10.1136/gutjnl-2018-317200
PubMed: 30377189
PubMed Central: PMC6352414
Affiliations:
- France, République populaire de Chine, États-Unis
- Floride, Guangdong, Midi-Pyrénées, Occitanie (région administrative), Texas
- Jiangmen, Toulouse
Links toward previous steps (curation, corpus...)
Le document en format XML
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promotes colorectal tumorigenesis through the action of cytolethal distending toxin.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Bacterial Toxins (toxicity)</term>
<term>Campylobacter jejuni (genetics)</term>
<term>Campylobacter jejuni (isolation & purification)</term>
<term>Campylobacter jejuni (pathogenicity)</term>
<term>Carcinogenesis (MeSH)</term>
<term>Colorectal Neoplasms (genetics)</term>
<term>Colorectal Neoplasms (microbiology)</term>
<term>DNA Damage (MeSH)</term>
<term>DNA, Neoplasm (analysis)</term>
<term>Feces (microbiology)</term>
<term>Gastrointestinal Microbiome (MeSH)</term>
<term>Gene Expression (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Mice (MeSH)</term>
<term>RNA, Neoplasm (analysis)</term>
<term>Sirolimus (pharmacology)</term>
<term>Transcriptome (MeSH)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>ADN tumoral (analyse)</term>
<term>ARN tumoral (analyse)</term>
<term>Altération de l'ADN (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Campylobacter jejuni (génétique)</term>
<term>Campylobacter jejuni (isolement et purification)</term>
<term>Campylobacter jejuni (pathogénicité)</term>
<term>Carcinogenèse (MeSH)</term>
<term>Expression des gènes (MeSH)</term>
<term>Fèces (microbiologie)</term>
<term>Humains (MeSH)</term>
<term>Microbiome gastro-intestinal (MeSH)</term>
<term>Sirolimus (pharmacologie)</term>
<term>Souris (MeSH)</term>
<term>Toxines bactériennes (toxicité)</term>
<term>Transcriptome (MeSH)</term>
<term>Tumeurs colorectales (génétique)</term>
<term>Tumeurs colorectales (microbiologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Neoplasm</term>
<term>RNA, Neoplasm</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Sirolimus</term>
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<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Bacterial Toxins</term>
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<term>ARN tumoral</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Campylobacter jejuni</term>
<term>Colorectal Neoplasms</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Campylobacter jejuni</term>
<term>Tumeurs colorectales</term>
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<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Campylobacter jejuni</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Campylobacter jejuni</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Fèces</term>
<term>Tumeurs colorectales</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Colorectal Neoplasms</term>
<term>Feces</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Campylobacter jejuni</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Campylobacter jejuni</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Sirolimus</term>
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<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Toxines bactériennes</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Carcinogenesis</term>
<term>DNA Damage</term>
<term>Gastrointestinal Microbiome</term>
<term>Gene Expression</term>
<term>Humans</term>
<term>Mice</term>
<term>Transcriptome</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Altération de l'ADN</term>
<term>Animaux</term>
<term>Carcinogenèse</term>
<term>Expression des gènes</term>
<term>Humains</term>
<term>Microbiome gastro-intestinal</term>
<term>Souris</term>
<term>Transcriptome</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p></p>
</div>
<div type="abstract" xml:lang="en"><p><b>DESIGN</b>
</p>
<p>Germ-free (GF) </p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>GF </p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Human clinical isolate </p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30377189</PMID>
<DateCompleted><Year>2019</Year>
<Month>01</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-3288</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>68</Volume>
<Issue>2</Issue>
<PubDate><Year>2019</Year>
<Month>02</Month>
</PubDate>
</JournalIssue>
<Title>Gut</Title>
<ISOAbbreviation>Gut</ISOAbbreviation>
</Journal>
<ArticleTitle><i>Campylobacter jejuni</i>
promotes colorectal tumorigenesis through the action of cytolethal distending toxin.</ArticleTitle>
<Pagination><MedlinePgn>289-300</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/gutjnl-2018-317200</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE"><i>Campylobacter jejuni</i>
produces a genotoxin, cytolethal distending toxin (CDT), which has DNAse activity and causes DNA double-strand breaks. Although <i>C. jejuni</i>
infection has been shown to promote intestinal inflammation, the impact of this bacterium on carcinogenesis has never been examined.</AbstractText>
<AbstractText Label="DESIGN">Germ-free (GF) <i>Apc<sup>Min/+</sup>
</i>
mice, fed with 1% dextran sulfate sodium, were used to test tumorigenesis potential of CDT-producing <i>C. jejuni</i>
. Cells and enteroids were exposed to bacterial lysates to determine DNA damage capacity via γH2AX immunofluorescence, comet assay and cell cycle assay. To examine the interplay of CDT-producing <i>C. jejuni</i>
, gut microbiome and host in tumorigenesis, colonic RNA-sequencing and faecal 16S rDNA sequencing were performed. Rapamycin was administrated to investigate the prevention of CDT-producing <i>C. jejuni</i>
-induced tumorigenesis.</AbstractText>
<AbstractText Label="RESULTS">GF <i>Apc<sup>Min/+</sup>
</i>
mice colonised with human clinical isolate <i>C. jejuni</i>
81-176 developed significantly more and larger tumours when compared with uninfected mice. <i>C. jejuni</i>
with a mutated <i>cdtB</i>
subunit, mut<i>cdtB</i>
, attenuated <i>C. jejuni</i>
-induced tumorigenesis in vivo and decreased DNA damage response in cells and enteroids. <i>C. jejuni</i>
infection induced expression of hundreds of colonic genes, with 22 genes dependent on the presence of c<i>dtB.</i>
The <i>C. jejuni</i>
-infected group had a significantly different microbial gene expression profile compared with the mut<i>cdtB</i>
group as shown by metatranscriptomic data, and different microbial communities as measured by 16S rDNA sequencing. Finally, rapamycin could diminish the tumorigenic capability of <i>C. jejuni</i>
.</AbstractText>
<AbstractText Label="CONCLUSION">Human clinical isolate <i>C. jejuni</i>
81-176 promotes colorectal cancer and induces changes in microbial composition and transcriptomic responses, a process dependent on CDT production.</AbstractText>
<CopyrightInformation>© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Zhen</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, Florida, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gharaibeh</LastName>
<ForeName>Raad Z</ForeName>
<Initials>RZ</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, Florida, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Newsome</LastName>
<ForeName>Rachel C</ForeName>
<Initials>RC</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, Florida, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pope</LastName>
<ForeName>Jllian L</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, Florida, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dougherty</LastName>
<ForeName>Michael W</ForeName>
<Initials>MW</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, Florida, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tomkovich</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, Florida, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pons</LastName>
<ForeName>Benoit</ForeName>
<Initials>B</Initials>
<Identifier Source="ORCID">0000-0002-9137-1047</Identifier>
<AffiliationInfo><Affiliation>Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRA, ENVT, INP- Purpan, UPS, Toulouse, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mirey</LastName>
<ForeName>Gladys</ForeName>
<Initials>G</Initials>
<Identifier Source="ORCID">0000-0002-0095-1864</Identifier>
<AffiliationInfo><Affiliation>Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRA, ENVT, INP- Purpan, UPS, Toulouse, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vignard</LastName>
<ForeName>Julien</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRA, ENVT, INP- Purpan, UPS, Toulouse, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hendrixson</LastName>
<ForeName>David R</ForeName>
<Initials>DR</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jobin</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, Florida, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Immunology, University of Florida, Gainesville, Florida, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 AI065539</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 DK073338</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>10</Month>
<Day>30</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Gut</MedlineTA>
<NlmUniqueID>2985108R</NlmUniqueID>
<ISSNLinking>0017-5749</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001427">Bacterial Toxins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004273">DNA, Neoplasm</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012334">RNA, Neoplasm</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C067044">cytolethal distending toxin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber>
<NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001427" MajorTopicYN="N">Bacterial Toxins</DescriptorName>
<QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016123" MajorTopicYN="N">Campylobacter jejuni</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D063646" MajorTopicYN="Y">Carcinogenesis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015179" MajorTopicYN="N">Colorectal Neoplasms</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004249" MajorTopicYN="N">DNA Damage</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004273" MajorTopicYN="N">DNA, Neoplasm</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005243" MajorTopicYN="N">Feces</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000069196" MajorTopicYN="N">Gastrointestinal Microbiome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012334" MajorTopicYN="N">RNA, Neoplasm</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059467" MajorTopicYN="N">Transcriptome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">bacterial enterotoxins</Keyword>
<Keyword MajorTopicYN="Y">campylobacter jejuni</Keyword>
<Keyword MajorTopicYN="Y">colon carcinogenesis</Keyword>
<Keyword MajorTopicYN="Y">infective colitis</Keyword>
</KeywordList>
<CoiStatement>Competing interests: None declared.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>07</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>09</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>10</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>11</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>1</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Day>1</Day>
<Hour>6</Hour>
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<affiliations><list><country><li>France</li>
<li>République populaire de Chine</li>
<li>États-Unis</li>
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<region><li>Floride</li>
<li>Guangdong</li>
<li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
<li>Texas</li>
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<settlement><li>Jiangmen</li>
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<tree><country name="États-Unis"><region name="Floride"><name sortKey="He, Zhen" sort="He, Zhen" uniqKey="He Z" first="Zhen" last="He">Zhen He</name>
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<name sortKey="Jobin, Christian" sort="Jobin, Christian" uniqKey="Jobin C" first="Christian" last="Jobin">Christian Jobin</name>
<name sortKey="Jobin, Christian" sort="Jobin, Christian" uniqKey="Jobin C" first="Christian" last="Jobin">Christian Jobin</name>
<name sortKey="Jobin, Christian" sort="Jobin, Christian" uniqKey="Jobin C" first="Christian" last="Jobin">Christian Jobin</name>
<name sortKey="Newsome, Rachel C" sort="Newsome, Rachel C" uniqKey="Newsome R" first="Rachel C" last="Newsome">Rachel C. Newsome</name>
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<name sortKey="Tomkovich, Sarah" sort="Tomkovich, Sarah" uniqKey="Tomkovich S" first="Sarah" last="Tomkovich">Sarah Tomkovich</name>
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<country name="République populaire de Chine"><region name="Guangdong"><name sortKey="He, Zhen" sort="He, Zhen" uniqKey="He Z" first="Zhen" last="He">Zhen He</name>
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<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Pons, Benoit" sort="Pons, Benoit" uniqKey="Pons B" first="Benoit" last="Pons">Benoit Pons</name>
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